BCAP31 Antikörper (Intermediate Domain)

Produktnummer ABIN499419

Der Kaninchen Polyklonal anti-BCAP31 Antikörper (ABIN499419) detektiert spezifisch BCAP31 in WB, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für BCAP31 Antikörper (Intermediate Domain) (ABIN499419)

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCAP31 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-BCAP31 Antikörper

Bindungsspezifität: Intermediate Domain

Spezifität: BAP31 antibody was raised against a 17 amino acid peptide from near the center of human BAP31.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Human BAP31 (Intermediate Domain) Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: BAP31 antibody can be used for the detection of BAP31 by Western blot at 0.5- 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BCAP31

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Andere Bezeichnung: BCAP31 / BAP31

Hintergrund: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family (1,2). These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18 (3,4). Bap31 may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria (5). Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopically, is also a potent inducer cell death (5).Synonyms: 6C6-AG tumor-associated antigen, B-cell receptor-associated protein 31, BCR-associated protein Bap31, DXS1357E, Protein CDM, p28 Bap31

Gen-ID: 10134

NCBI Accession: NP_005736

UniProt: P51572

Pathways: Positive Regulation of Endopeptidase Activity