AVEN Antikörper (C-Term)

Produktnummer ABIN499367

Der Kaninchen Polyklonal anti-AVEN Antikörper wird verwendet zum Nachweis von AVEN in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für AVEN Antikörper (C-Term) (ABIN499367)

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AVEN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-AVEN Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to AVEN.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Aven antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Aven.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Aven antibody can be used for detection of Aven at 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Andere Bezeichnung: AVEN

Hintergrund: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.Synonyms: Cell death regulator Aven, PDCD12, Programmed cell death 12

Gen-ID: 57099

NCBI Accession: NP_065104

UniProt: Q9NQS1