ANTXR1 Antikörper (C-Term)

Produktnummer ABIN499365

Dieses Anti-ANTXR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ANTXR1 in WB, IF und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ANTXR1 Antikörper (C-Term) (ABIN499365)

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANTXR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-ANTXR1 Antikörper

Bindungsspezifität: C-Term

Spezifität: ATR antibody was raised against a peptide corresponding to 13 amino acids near the C-terminus of human ATR. ATR will recognize only the largest isoform.

Aufreinigung: Ion exchange chromatography

Immunogen: Human ATR / TEM8 (C-Terminus) Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: ATR antibody can be used for detection of ATR by Western blot at 1 to 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu ANTXR1

Target: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Andere Bezeichnung: Anthrax Toxin Receptor 1

Hintergrund: The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell, acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).Synonyms: ANTXR1, ATR, TEM8, Tumor endothelial marker 8

Gen-ID: 84168

NCBI Accession: NP_444262

UniProt: Q9H6X2