ATOH8 Antikörper (C-Term)

Produktnummer ABIN499361

Der Kaninchen Polyklonal Anti-ATOH8-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, ATOH8 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ATOH8 Antikörper (C-Term) (ABIN499361)

Target: ATOH8 (Atonal Homolog 8 (ATOH8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATOH8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-ATOH8 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to ATOH8.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: ATOH8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human ATOH8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: ATOH8 antibody can be used for detection of ATOH8 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu ATOH8

Target: ATOH8 (Atonal Homolog 8 (ATOH8))

Andere Bezeichnung: ATOH8

Hintergrund: Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57 % identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.Synonyms: Helix-loop-helix protein hATH-6, Protein atonal homolog 8, hATH-6, hATH6

Gen-ID: 84913

NCBI Accession: NP_116216

UniProt: Q96SQ7

Pathways: Regulation of Muscle Cell Differentiation