AKIRIN2 Antikörper (Center)

Produktnummer ABIN499259

Der Kaninchen Polyklonal Anti-AKIRIN2-Antikörper wurde für WB und EIA validiert. Er ist geeignet, AKIRIN2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für AKIRIN2 Antikörper (Center) (ABIN499259)

Target: AKIRIN2 (Akirin 2 (AKIRIN2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKIRIN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-AKIRIN2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody reacts to AKIRIN-2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Akirin2 antibody was raised against a 15 amino acid peptide near the center of the human Akirin2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Akirin2 antibody can be used for detection of Akirin2 at 0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu AKIRIN2

Target: AKIRIN2 (Akirin 2 (AKIRIN2))

Andere Bezeichnung: AKIRIN2 / C6orf166

Hintergrund: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.Synonyms: Akirin-2

Gen-ID: 55122

UniProt: Q53H80

Pathways: Positive Regulation of Endopeptidase Activity