GRAP2 Antikörper

Produktnummer ABIN499081

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GRAP2 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GRAP2 Antikörper (ABIN499081)

Target: GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GRAP2 Antikörper

Spezifität: This antibody detects endogenous levels of GRAP2 protein. (region surrounding asn158)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu GRAP2

Target: GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))

Andere Bezeichnung: GRAP2

Hintergrund: In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-γ, within structural proteins, such as spectrin or myosin, and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids that bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. Deletion or mutation of SH3 domains generally activates the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. Gads is an adapter proteins that contains both SH2 and SH3 domains. Gads binds to tyrosine-phosphorylated proteins, such as Shc, and functions to couple these proteins to downstream effectors.Synonyms: Adapter protein GRID, GADS, GRB-2-like protein, GRB2-related adapter protein 2, GRB2L, GRBLG, GRBX, GRID, Grf-40, Grf40 adapter protein, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, SH3-SH2-SH3 adapter Mona

Molekulargewicht: approx. 38 kDa

Gen-ID: 9402

NCBI Accession: NP_004801

UniProt: O75791

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung