FX antikoerper, P35B antikoerper, SDR4E1 antikoerper, AI256181 antikoerper, Tstap35b antikoerper, p35b antikoerper, sdr4e1 antikoerper, TSTA3 antikoerper, zgc:101805 antikoerper, si:dkey-235d18none antikoerper, Fx antikoerper, tissue specific transplantation antigen P35B antikoerper, tissue specific transplantation antigen P35B L homeolog antikoerper, TSTA3 antikoerper, Tsta3 antikoerper, tsta3 antikoerper, tsta3.L antikoerper
Hintergrund
GDP-L-fucose synthetase (FX protein), also designated Tissue-specific transplantation antigen P35B or GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, belongs to the fucose synthetase family. FX is a red cell NADP(H)- binding protein that is important in leukocyte adhesion and trafficking processes. The FX protein, together with GDP-mannose 4,6-dehydratase, can convert GDP-mannose to GDP-L-fucose by catalyzing the two-step epimerase and reductase reactions. GDP-L-fucose is the substrate of several fucosyltransferases that function in the expression of many glycoconjugates such as blood group ABH antigens and developmental adhesion antigens. Defects in the gene encoding for the FX protein cause leukocyte adhesion deficiency (LAD).Synonyms: 5-epimerase-4-reductase, GDP-4-keto-6-deoxy-D-mannose-3, GDP-L-fucose synthetase, Protein FX, Red cell NADP(H)-binding protein, SDR4E1, Short chain dehydrogenase/reductase family 4E member 1