FOLR1 Antikörper

Produktnummer ABIN499072

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FOLR1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für FOLR1 Antikörper (ABIN499072)

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOLR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FOLR1 Antikörper

Spezifität: This antibody detects endogenous levels of FR-α (Y80) protein. (region surrounding Tyr80)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Andere Bezeichnung: Folate Receptor alpha

Hintergrund: Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, α, β, γ, γ' (which is produced by alternative splicing) and δ. β-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. γ-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of δ-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The α isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.Synonyms: Adult folate-binding protein, FOLR, FOLR1, FR-alpha, Folate receptor 1, KB cells FBP, MOv18, Ovarian tumor-associated antigen MOv18

Molekulargewicht: approx. 34 kDa

Gen-ID: 2348

NCBI Accession: NP_000793

UniProt: P15328

Pathways: Dicarboxylic Acid Transport