Superoxide dismutase copper chaperone Antikörper

Produktnummer ABIN499056

Produktdetails anti-Superoxide dismutase copper chaperone Antikörper

Target: Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Superoxide dismutase copper chaperone Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of CCCS protein. (region surrounding Pro271)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Superoxide dismutase copper chaperone

Target: Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))

Andere Bezeichnung: CCS (CCS Produkte)

Synonyme: ccs antikoerper, MGC82563 antikoerper, CCS antikoerper, DDBDRAFT_0189222 antikoerper, DDBDRAFT_0238038 antikoerper, DDB_0189222 antikoerper, DDB_0238038 antikoerper, ATCCS antikoerper, COPPER/ZINC SUPEROXIDE DISMUTASE COPPER CHAPERONE antikoerper, F5O11.26 antikoerper, F5O11_26 antikoerper, copper chaperone for SOD1 antikoerper, Ccsd antikoerper, copper chaperone for superoxide dismutase L homeolog antikoerper, copper chaperone for superoxide dismutase antikoerper, copper chaperone for SOD1 antikoerper, ccs.L antikoerper, ccs antikoerper, CCS antikoerper, LOC552629 antikoerper, Ccs antikoerper

Hintergrund: Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Copper chaperone for SOD-1 (CCS) is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. CCS interacts with both wildtype and mutated forms of SOD-1 through CCS domains that are homologous in SOD-1. CCS exists as a homodimer that may form a heterodimer with SOD-1 during copper loading. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. The gene for CCS maps to human chromosome 11q13.Synonyms: SOD-4, Superoxide Dismutase Copper Chaperone

Molekulargewicht: approx. 32 kDa

Gen-ID: 9973

NCBI Accession: NP_005116

UniProt: O14618

Pathways: Transition Metal Ion Homeostasis