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CrkL Antikörper (pTyr207)
CRKL
Reaktivität: Human, Maus, Ratte
IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-CrkL Antikörper
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Target
Alle CrkL (CRKL) Antikörper anzeigen
CrkL (CRKL)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
Bindungsspezifität
Alle Epitope für CrkL Antikörper
pTyr207
Reaktivität
Alle Reaktivitäten für CrkL Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für CrkL Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für CrkL Antikörper
Polyklonal
Konjugat
Alle Konjugate für CrkL Antikörper
Dieser CrkL Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CrkL Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of p-CrkL protein only when phosphorylated at Try207.
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu CrkL
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Target
CrkL (CRKL)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
Andere Bezeichnung
CRKL (CRKL Produkte )
Synonyme
CRKL antikoerper, wu:fa55g05 antikoerper, wu:fj60e01 antikoerper, zgc:63469 antikoerper, 1110025F07Rik antikoerper, AA589403 antikoerper, AI325100 antikoerper, Crkol antikoerper, CRK like proto-oncogene, adaptor protein antikoerper, v-crk avian sarcoma virus CT10 oncogene homolog-like antikoerper, CRKL antikoerper, crkl antikoerper, Crkl antikoerper
Hintergrund
Crk, is a transformation-specific protein that induces elevation of cellular phosphotyrosine levels, but lacks tyrosine kinase activity itself. A second protein, Nck, consists solely of three SH3 domains and one SH2 domain, while GRB2 contains an SH2 domain flanked on both sides by SH3 domains. A member of this protein class, Crk-L, is encoded by a gene located on chromosome 22, band 11, centromeric of the chronic myelogenous leukemia breakpoint region. Crk-L encodes a 303 amino acid protein with one SH2 and two SH3 domains, and a predicted molecular weight of 36 kDa.Synonyms: Crk-like protein, v-crk avian sarcoma virus CT10 oncogene homolog-like
Molekulargewicht
approx. 39 kDa
Gen-ID
1399
NCBI Accession
NP_005198
UniProt
P46109
Pathways
Interferon-gamma Pathway , Neurotrophin Signalübertragung , Signaling of Hepatocyte Growth Factor Receptor
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