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Crk Antikörper (pTyr221)
CRK
Reaktivität: Human, Maus, Ratte
IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-Crk Antikörper
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Target
Alle Crk (CRK) Antikörper anzeigen
Crk (CRK)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
Bindungsspezifität
Alle Epitope für Crk Antikörper
pTyr221
Reaktivität
Alle Reaktivitäten für Crk Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für Crk Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Crk Antikörper
Polyklonal
Konjugat
Alle Konjugate für Crk Antikörper
Dieser Crk Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Crk Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of p-Crk2 protein only when phosphorylated at Try221.
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu Crk
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Target
Crk (CRK)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
Andere Bezeichnung
CRK (CRK Produkte )
Synonyme
CG1587 antikoerper, CRK antikoerper, D-CRK antikoerper, D-Crk antikoerper, DCrk antikoerper, Dcrk antikoerper, Dmel\\CG1587 antikoerper, crk antikoerper, dCRK antikoerper, dCrk antikoerper, fb34h10 antikoerper, fc05a01 antikoerper, fi19g05 antikoerper, wu:fb34h10 antikoerper, wu:fc05a01 antikoerper, wu:fc54a04 antikoerper, wu:fi19g05 antikoerper, zgc:100936 antikoerper, CRKII antikoerper, p38 antikoerper, Crko antikoerper, crk2 antikoerper, crkII antikoerper, v-crk antikoerper, P38C-CRK antikoerper, Crk-I antikoerper, Crk-II antikoerper, Crk-III antikoerper, Crk3 antikoerper, CrkIII antikoerper, c-Crk antikoerper, Crk oncogene antikoerper, v-crk avian sarcoma virus CT10 oncogene homolog antikoerper, CRK proto-oncogene, adaptor protein antikoerper, v-crk avian sarcoma virus CT10 oncogene homolog L homeolog antikoerper, v-crk sarcoma virus CT10 oncogene homolog antikoerper, Crk antikoerper, crk antikoerper, CRK antikoerper, crk.L antikoerper
Hintergrund
The Crk family of adapter proteins including Crk II, Crk I and Crk L consist mostly of SH2 and SH3 domains. Through the interactions between SH2 domain and phosphotyrosine residues and/or between SH3 domain and proline- rich motifs, they are involved in a variety of signaling cascades. Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor-I (IGFI) and might be involved in the IGF-I receptor signalling pathway. The gene encoding Crk I and II maps to human chromosome 17p13, a region which demonstrates frequent deletion or loss of heterozygosity in a wide range of human cancers.Synonyms: Adapter molecule crk, Proto-oncogene C-crk, p38
Molekulargewicht
approx. 42 kDa
Gen-ID
1398
NCBI Accession
NP_005197
UniProt
P46108
Pathways
Neurotrophin Signalübertragung , CXCR4-mediated Signaling Events , Signaling of Hepatocyte Growth Factor Receptor
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