NPY Antikörper

Produktnummer ABIN498562

Produktdetails anti-NPY Antikörper

Target: NPY (Neuropeptide Y (NPY))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPY Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of NPY protein. (region surrounding Pro94)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu NPY

Target: NPY (Neuropeptide Y (NPY))

Andere Bezeichnung: Neuropeptide Y / NPY (NPY Produkte)

Synonyme: 0710005A05Rik antikoerper, PYY4 antikoerper, NPY02 antikoerper, RATNPY antikoerper, RATNPY02 antikoerper, si:dkey-22m8.5 antikoerper, npy antikoerper, npyb antikoerper, preproNPY antikoerper, pyy4 antikoerper, xnpy antikoerper, npya antikoerper, MGC86288 antikoerper, prepronpy antikoerper, NPY antikoerper, NPY1 antikoerper, neuropeptide Y antikoerper, neuropeptide Y S homeolog antikoerper, neuropeptide Y L homeolog antikoerper, Npy antikoerper, NPY antikoerper, npy antikoerper, npy.S antikoerper, npy.L antikoerper, LOC100533423 antikoerper

Hintergrund: A gene located on chromosome 7p15.1 encodes a 36-amino acid protein designated NPY (Neuropeptide Y). NPY consists of a polyproline stretch followed by an amphipathic alphahelix. NPY shares a 50 % amino acid homology with pancreatic polypeptide gene (PP). The NPY hormone family consists of NPY, PP and peptide YY. NPY is expressed throughout the central and peripheral nervous system, particularly in the deep layers of the cortex and smaller cell bodies in the white matter. NPY interacts with the Y-receptor family of G-protein coupled receptors. NPY interacts with NPY receptor Y1 to increase corticotropin levels and decrease noradrenaline levels in the hypothalamus. Through interactions in the hypothalus, NPY plays important roles in the regulation of energy balance by stimulating food intake. NPY favors energy storage by increasing lipoprotein lipase activity in white adipose tissue. A leucine(7)-to- proline(7) polymorphism has been implicated in an increase in alcohol preference, and decrease in cholesterol metabolism.

Molekulargewicht: approx. 11 kDa

Gen-ID: 4852

NCBI Accession: NP_000896

UniProt: P01303

Pathways: Feeding Behaviour