PAX1 Antikörper
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- Target Alle PAX1 Antikörper anzeigen
- PAX1 (Paired Box 1 (PAX1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PAX1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of Pax-1 protein. (region surrounding Thr367)
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human.
- Aufreinigung
- Affinity chromatography using epitope-specific immunogen
- Reinheit
- > 95 % (by SDS-PAGE)
- Top Product
- Discover our top product PAX1 Primärantikörper
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- Applikationshinweise
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- PAX1 (Paired Box 1 (PAX1))
- Andere Bezeichnung
- PAX1 (PAX1 Produkte)
- Synonyme
- hup48 antikoerper, pax-1 antikoerper, HUP48 antikoerper, Pax-1 antikoerper, hbs antikoerper, hunchback antikoerper, un antikoerper, undulated antikoerper, wt antikoerper, paired box 1 antikoerper, paired box 1 S homeolog antikoerper, PAX1 antikoerper, pax1 antikoerper, Pax1 antikoerper, pax1.S antikoerper
- Hintergrund
- Pax genes contain paired domains with strong homology to genes in Drosophila that are involved in programming early development. Pax-1 is a sequence-specific DNA binding-protein with transcriptional activating properties. The expression pattern of Pax-1 during mouse embryogenesis indicates that it may play an important role in the development of the vertebral column. The autosomal recessive mutation 'undulated' (un) in the mouse exhibits vertebral anomalies along the entire rostrocaudal axis and is associated with a point mutation (G-to-A transition) at position 15 leading to a gly-to-ser replacement in a highly conserved region of the paired box of Pax-1. Pax-1 is required for the normal development of these three skeletal elements: the vertebral column, sternum, and scapula. Mice who are doubly heterozygous for the mutants 'undulated' and 'Patch' have a phenotype reminiscent of an extreme form of spina bifida occulta in humans. The gene which encodes Pax-1 maps to human chromosome 20p11.2.Synonyms: HUP48, Paired box protein Pax-1, Pax-1
- Molekulargewicht
- approx. 36 kDa
- Gen-ID
- 5075
- NCBI Accession
- NP_006183
- UniProt
- P15863
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