CDC42BPB Antikörper

Produktnummer ABIN498363

Der Kaninchen Polyklonal anti-CDC42BPB Antikörper (ABIN498363) detektiert spezifisch CDC42BPB in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für CDC42BPB Antikörper (ABIN498363)

Target: CDC42BPB (CDC42 Binding Protein Kinase beta (DMPK-Like) (CDC42BPB))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC42BPB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CDC42BPB Antikörper

Spezifität: This antibody detects endogenous levels of MRCKbeta protein. (region surrounding Phe1665)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CDC42BPB

Target: CDC42BPB (CDC42 Binding Protein Kinase beta (DMPK-Like) (CDC42BPB))

Andere Bezeichnung: CDC42BPB

Hintergrund: Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues. Myotonic dystrophy kinaserelated Cdc42-binding (DMPK-like) kinases-alpha and beta (MRCK-alpha, beta) contain a cysteine-rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle Myosin light chain and influences Actin-Myosin contractility. MRCK-alpha can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/Cofilin and to Actin cytoskeletal reorganization. MRCK-alpha can also influence neurite outgrowth promoted by Cdc42 and Rac.Synonyms: CDC42-binding protein kinase beta, DMPK-like beta, KIAA1124, MRCK beta, Myotonic dystrophy kinase-related CDC42-binding kinase beta, Serine/threonine-protein kinase MRCK beta

Molekulargewicht: approx. 194 kDa

Gen-ID: 9578

NCBI Accession: NP_006026

UniProt: Q9Y5S2