CCAR2 Antikörper

Produktnummer ABIN498347

Der Kaninchen Polyklonal anti-CCAR2 Antikörper wird verwendet zum Nachweis von CCAR2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für CCAR2 Antikörper (ABIN498347)

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCAR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CCAR2 Antikörper

Spezifität: This antibody detects endogenous levels of KIAA1967 / DBC-1 protein. (region surrounding Gln455)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % pure SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM Sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CCAR2

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Andere Bezeichnung: KIAA1967

Hintergrund: KIAA1967 / DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8 (8p21-8p23) that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFα, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFalpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ERalpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.Synonyms: DBC-1, DBC.1, DBC1, Deleted in breast cancer gene 1 protein, KIAA1967, p30 DBC

Molekulargewicht: approx. 102.0 kDa

Gen-ID: 57805

NCBI Accession: NP_066997

UniProt: Q8N163