KAT5 Antikörper

Produktnummer ABIN498216

Produktdetails anti-KAT5 Antikörper

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KAT5 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of TIP60 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: KAT5 (KAT5 Produkte)

Synonyme: 6121 antikoerper, CG6121 antikoerper, DmEG0007.7 antikoerper, Dmel/TIP60 antikoerper, Dmel\\CG6121 antikoerper, Dmel\\TIP60 antikoerper, EG0007.7 antikoerper, EG:EG0007.7 antikoerper, TIP60 antikoerper, dTIP60 antikoerper, dTip60 antikoerper, dmHAG405 antikoerper, im:6908768 antikoerper, wu:fb55b08 antikoerper, zgc:110752 antikoerper, ESA1 antikoerper, HTATIP antikoerper, HTATIP1 antikoerper, PLIP antikoerper, TIP antikoerper, ZC2HC5 antikoerper, cPLA2 antikoerper, AI839539 antikoerper, CPLA2 antikoerper, Htatip antikoerper, Htatip1 antikoerper, Tip55 antikoerper, Tip60 antikoerper, K(lysine) acetyltransferase 5a antikoerper, lysine acetyltransferase 5 antikoerper, Tat interactive protein 60kDa antikoerper, histone acetyltransferase Tip60 antikoerper, tip60, putative antikoerper, K(lysine) acetyltransferase 5b antikoerper, K(lysine) acetyltransferase 5 antikoerper, kat5a antikoerper, KAT5 antikoerper, Tip60 antikoerper, LOC413101 antikoerper, LOC5579231 antikoerper, Smp_053140 antikoerper, kat5b antikoerper, Kat5 antikoerper

Hintergrund: MOZ (monocytic leukemia zinc-finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional co-activator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ-related proteins, including MORF (MOZrelated factor) and TIP60 (TAT-interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N-terminus and a highly potent activation domain at the C-terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. TIP60 was originally identified as a co-activator for the HIV TAT protein and also functions as a nuclear hormone receptor co-activator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.Synonyms: 60 kDa Tat-interactive protein, HIV-1 Tat interactive protein, HTATIP, Histone acetyltransferase HTATIP, Histone acetyltransferase KAT5, Lysine acetyltransferase 5, PLIP, TIP60, cPLA(2)-interacting protein

Gen-ID: 10524

NCBI Accession: NP_006379

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway