HSD17B10 Antikörper

Produktnummer ABIN498183

Produktdetails anti-HSD17B10 Antikörper

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSD17B10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of HADH2 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu HSD17B10

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Andere Bezeichnung: HSD17B10 / ERAB (HSD17B10 Produkte)

Synonyme: hadh2 antikoerper, im:6899159 antikoerper, wu:fj61f03 antikoerper, zgc:101605 antikoerper, abad antikoerper, camr antikoerper, erab antikoerper, hcd2 antikoerper, hsd10 antikoerper, mhbd antikoerper, mrpp2 antikoerper, mrx17 antikoerper, mrx31 antikoerper, mrxs10 antikoerper, schad antikoerper, sdr5c1 antikoerper, HADH2 antikoerper, HSD17B10 antikoerper, 17b-HSD10 antikoerper, ABAD antikoerper, CAMR antikoerper, DUPXp11.22 antikoerper, ERAB antikoerper, HCD2 antikoerper, MHBD antikoerper, MRPP2 antikoerper, MRX17 antikoerper, MRX31 antikoerper, MRXS10 antikoerper, SCHAD antikoerper, SDR5C1 antikoerper, 17bHSD10 antikoerper, Ads9 antikoerper, Hadh2 antikoerper, hydroxysteroid (17-beta) dehydrogenase 10 antikoerper, hydroxysteroid 17-beta dehydrogenase 10 antikoerper, hydroxysteroid (17-beta) dehydrogenase 10 L homeolog antikoerper, HSD17B10 antikoerper, hsd17b10 antikoerper, hsd17b10.L antikoerper, Hsd17b10 antikoerper

Hintergrund: β-Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimer's disease. β-Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of β-Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum-associated β-Amyloid-binding protein. ERAB is characterized as a NAD+-dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimer's disease. Cells overexpressing ERAB in vitro have been shown to be more sensitive to β-Amyloid-induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that β-Amyloid induced cell death is mediated by ERAB.Synonyms: 17-beta-HSD10, 17-beta-hydroxysteroid dehydrogenase 10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, 3-hydroxyacyl-CoA dehydrogenase type-2, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, HADH2, MRPP2, Mitochondrial Marker, Mitochondrial ribonuclease P protein 2, SCHAD, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, XH98G2

Molekulargewicht: approx. 27 kDa

Gen-ID: 3028

NCBI Accession: NP_001032900

UniProt: Q99714