IFNGR1 Antikörper

Produktnummer ABIN498146

Produktdetails anti-IFNGR1 Antikörper

Target: IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFNGR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of IFN-γRα protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IFNGR1

Target: IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))

Andere Bezeichnung: CD119 / IFNGR1 (IFNGR1 Produkte)

Synonyme: CD119 antikoerper, IFNGR antikoerper, IFN-gammaR antikoerper, Ifgr antikoerper, Ifngr antikoerper, Nktar antikoerper, IFNGR1 antikoerper, MGC129098 antikoerper, ifngr1 antikoerper, MGC194858 antikoerper, MGC194873 antikoerper, zgc:194858 antikoerper, cd119 antikoerper, ifngr antikoerper, DKFZp469K1232 antikoerper, interferon gamma receptor 1 antikoerper, cytokine receptor family member B17 antikoerper, IFNGR1 antikoerper, Ifngr1 antikoerper, crfb17 antikoerper, ifngr1 antikoerper

Hintergrund: IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains.Synonyms: IFN-gamma-R1, Interferon-gamma receptor alpha chain

Molekulargewicht: approx. 83 kDa

Gen-ID: 3459

NCBI Accession: NP_000407

UniProt: P15260

Pathways: Interferon-gamma Pathway