PBX1 Antikörper (Internal Region)

Produktnummer ABIN498074

Produktdetails anti-PBX1 Antikörper

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-ATNVSAHGSQ ANSPS

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog).
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide from the internal region of the protein sequence according to NP_002576.1. Genename: PBX1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Detection Limit: 1/32000. Western blot: 0.5-1.5 μg/mL. Detects a band of Approx 45 kDa in lysates of cell line K562.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine (Dog). Add. Information: Calculated Molecular Weight: 46.5 kDa according to NP_002576.1

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PBX1

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Andere Bezeichnung: PBX1 (PBX1 Produkte)

Synonyme: fi29e01 antikoerper, pbx1b antikoerper, wu:fi29e01 antikoerper, zgc:55265 antikoerper, 2310056B04Rik antikoerper, AI848790 antikoerper, AU015730 antikoerper, D230003C07Rik antikoerper, Pbx-1 antikoerper, Pbx1a antikoerper, Pbx1b antikoerper, PBX1A antikoerper, Xpbx1 antikoerper, Xpbx1b antikoerper, PBX homeobox 1 antikoerper, pre-B-cell leukemia homeobox 1a antikoerper, pre B cell leukemia homeobox 1 antikoerper, pre-B-cell leukemia homeobox 1 S homeolog antikoerper, PBX1 antikoerper, pbx1a antikoerper, Pbx1 antikoerper, pbx1.S antikoerper

Hintergrund: This nonactivating protein which could be a repressor, binds the sequence 5'-ATCAATCAA-3'. It is converted into a potent transcriptional activator by the (1,19) translocation. PBX1 May have a role in steroidogenesis and subsequently sexual development and differentiation, and is expressed in all tissues except in cells of the B and T lineage. PBX1 is involved in a form of pre-B-cell acute lymphoblastic leukemia (B-ALL) (25 % of human pediatric cases) through a chromosomal translocation t(1,19)(q23,p13.3) which involves PBX1 and E2A genes. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. PBX1 belongs to the TALE/PBX homeobox family, and contains 1 homeobox domain.Synonyms: Homeobox protein PBX1, Homeobox protein PRL, Pre-B-cell leukemia transcription factor 1

Gen-ID: 5087

NCBI Accession: NP_002576

UniProt: P40424