SYVN1 Antikörper (AA 586-617)

Produktnummer ABIN3029082

Produktdetails anti-SYVN1 Antikörper

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Bindungsspezifität: AA 586-617

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYVN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: Purified

Immunogen: A portion of amino acids 586-617 from the human protein was used as the immunogen for this SYVN1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the SYVN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:200-1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SYVN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu SYVN1

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Andere Bezeichnung: SYVN1 (HRD1) (SYVN1 Produkte)

Synonyme: DER3 antikoerper, HRD1 antikoerper, hrd1 antikoerper, 1200010C09Rik antikoerper, AW211966 antikoerper, C85322 antikoerper, D530017H19Rik antikoerper, Hrd1 antikoerper, RGD1310488 antikoerper, syvn1 antikoerper, syvn1-a antikoerper, syvn1-b antikoerper, wu:fk91f10 antikoerper, zgc:55735 antikoerper, zgc:77108 antikoerper, synoviolin 1 antikoerper, synovial apoptosis inhibitor 1, synoviolin antikoerper, synoviolin 1 S homeolog antikoerper, SYVN1 antikoerper, syvn1 antikoerper, Syvn1 antikoerper, syvn1.S antikoerper

Hintergrund: HRD1/SYVN1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of SYVN1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. It is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects.

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling