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SIGLEC7 Antikörper (AA 1-30)

SIGLEC7 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3032556
  • Target Alle SIGLEC7 Antikörper anzeigen
    SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
    Bindungsspezifität
    • 10
    • 8
    • 8
    • 8
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30
    Reaktivität
    • 86
    • 12
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 62
    • 24
    Kaninchen
    Klonalität
    • 62
    • 23
    • 1
    Polyklonal
    Konjugat
    • 37
    • 12
    • 10
    • 9
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIGLEC7 Antikörper ist unkonjugiert
    Applikation
    • 63
    • 43
    • 39
    • 17
    • 10
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 1-30 from the human protein was used as the immunogen for this SIGLEC7 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SIGLEC7 Primärantikörper
  • Applikationshinweise
    Titration of the SIGLEC7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the SIGLEC7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
    Andere Bezeichnung
    SIGLEC7 (SIGLEC7 Produkte)
    Synonyme
    SIGLEC7 antikoerper, AIRM1 antikoerper, CD328 antikoerper, CDw328 antikoerper, D-siglec antikoerper, QA79 antikoerper, SIGLEC-7 antikoerper, SIGLEC19P antikoerper, SIGLECP2 antikoerper, p75 antikoerper, p75/AIRM1 antikoerper, sialic acid-binding Ig-like lectin 7 antikoerper, sialic acid binding Ig like lectin 7 antikoerper, LOC468976 antikoerper, SIGLEC7 antikoerper
    Hintergrund
    SIGLECs are cell surface proteins of the Ig superfamily. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. A large subgroup of SIGLECs share high homology with SIGLEC3 (CD33) and are localized to 19q13.4. The cDNA for the SLG gene encodes 2 variants, SLG-long (SLGL) and SLG-short (SLGS). The 595-amino acid SLGL protein contains a signal peptide and 2 V-set N-terminal Ig-like domains. The 477-amino acid SLGS protein has a weak signal sequence and, like most SIGLEC3-like SIGLECs, has only 1 V-set N-terminal Ig-like domain. Both variants contain 2 C2-set N-terminal Ig-like domains, a transmembrane domain, and a cytoplasmic tail with a putative ITIM and a putative SLAM-like tyrosine-based motif. The conserved arginine residue thought to be essential for sialic acid binding in other SIGLECs is replaced by a glutamine in SLGS and by a cysteine in SLGL. RT-PCR analysis detected high expression of both variants in spleen and small intestine, and SLGS was highly expressed in adrenal gland and SLGL was highly expressed in bone marrow.
    UniProt
    Q9Y286
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