Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PROX1 Antikörper (AA 175-206)

PROX1 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3032344
  • Target Alle PROX1 Antikörper anzeigen
    PROX1 (Prospero Homeobox 1 (PROX1))
    Bindungsspezifität
    • 16
    • 14
    • 12
    • 9
    • 9
    • 8
    • 8
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 175-206
    Reaktivität
    • 102
    • 48
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 94
    • 8
    Kaninchen
    Klonalität
    • 92
    • 10
    Polyklonal
    Konjugat
    • 47
    • 10
    • 10
    • 9
    • 8
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PROX1 Antikörper ist unkonjugiert
    Applikation
    • 92
    • 57
    • 42
    • 28
    • 13
    • 11
    • 10
    • 4
    • 2
    • 2
    Western Blotting (WB), ELISA
    Kreuzreaktivität (Details)
    Expected species reactivity: Mouse
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 175-206 from the human protein was used as the immunogen for this PROX1 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product PROX1 Primärantikörper
  • Applikationshinweise
    Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the PROX1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PROX1 (Prospero Homeobox 1 (PROX1))
    Andere Bezeichnung
    PROX1 (PROX1 Produkte)
    Synonyme
    xprox1 antikoerper, prospero antikoerper, PROX1 antikoerper, LOC100232600 antikoerper, A230003G05Rik antikoerper, prox1 antikoerper, zgc:111888 antikoerper, prospero homeobox 1 antikoerper, prospero homeobox 1 L homeolog antikoerper, prospero homeobox 1a antikoerper, PROX1 antikoerper, prox1.L antikoerper, prox1 antikoerper, Prox1 antikoerper, prox1a antikoerper
    Hintergrund
    The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.
    UniProt
    Q92786
    Pathways
    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
Sie sind hier:
Kundenservice