MAP4K4 Antikörper (AA 618-649)

Produktnummer ABIN3031854

Produktdetails anti-MAP4K4 Antikörper

Target: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Bindungsspezifität: AA 618-649

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP4K4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Purified

Immunogen: A portion of amino acids 618-649 from the human protein was used as the immunogen for this NIK antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the NIK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the NIK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MAP4K4

Target: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Andere Bezeichnung: NIK (Nck-Interacting Kinase) (MAP4K4 Produkte)

Synonyme: FLH21957 antikoerper, HGK antikoerper, MEKKK4 antikoerper, NIK antikoerper, 9430080K19Rik antikoerper, AU043147 antikoerper, AU045934 antikoerper, AW046177 antikoerper, Nik antikoerper, mitogen-activated protein kinase kinase kinase kinase 4 antikoerper, MAP4K4 antikoerper, Map4k4 antikoerper

Hintergrund: HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK/NIK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.

UniProt: O95819