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MUC4 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MUC4 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN3031870

Kurzübersicht für MUC4 Antikörper (N-Term) (ABIN3031870)

Target

Alle MUC4 Antikörper anzeigen
MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reaktivität

  • 67
  • 15
  • 6
  • 1
Human

Wirt

  • 36
  • 36
Kaninchen

Klonalität

  • 45
  • 27
Polyklonal

Konjugat

  • 45
  • 7
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MUC4 Antikörper ist unkonjugiert

Applikation

  • 45
  • 36
  • 20
  • 15
  • 12
  • 10
  • 6
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 24
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Aufreinigung

    Antigen affinity purified

    Immunogen

    This MUC4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human Mucin-4 alpha chain.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    Titration of the MUC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Aliquot the MUC4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    MUC4 (Mucin 4, Cell Surface Associated (MUC4))

    Andere Bezeichnung

    Mucin-4 alpha chain / MUC4

    Hintergrund

    May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

    UniProt

    Q99102

    Pathways

    Regulation of Leukocyte Mediated Immunity
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