MUC1 Antikörper (AA 1176-1205)

Produktnummer ABIN3031859

Der Kaninchen Polyklonal Anti-MUC1-Antikörper wurde für IHC, WB und ELISA validiert. Er ist geeignet, MUC1 in Proben von Human zu detektieren.

Kurzübersicht für MUC1 Antikörper (AA 1176-1205) (ABIN3031859)

Target: MUC1 (Mucin 1 (MUC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Produktdetails anti-MUC1 Antikörper

Bindungsspezifität: AA 1176-1205

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 1176-1205 from the human protein was used as the immunogen for this MUC-1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the MUC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MUC-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MUC1

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: MUC-1

Hintergrund: This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq].

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling