MIB1 Antikörper (AA 13-42)
Kurzübersicht für MIB1 Antikörper (AA 13-42) (ABIN3031774)
Target
Alle MIB1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 13-42
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Verwendungszweck
- Mib1 Antibody
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Kreuzreaktivität (Details)
- Expected species reactivity: Mouse, Zebrafish, Xenopus
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Aufreinigung
- Purified
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Immunogen
- A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.
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Isotyp
- Ig Fraction
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Applikationshinweise
- Titration of the Mib1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the Mib1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
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Andere Bezeichnung
- Mib1
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Hintergrund
- MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
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UniProt
- Q86YT6
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Pathways
- SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
Target
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