MARK1 Antikörper (AA 6-40)

Produktnummer ABIN3031687

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MARK1 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für MARK1 Antikörper (AA 6-40) (ABIN3031687)

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MARK1 Antikörper

Bindungsspezifität: AA 6-40

Aufreinigung: Purified

Immunogen: A portion of amino acids 6-40 from the human protein was used as the immunogen for this MARK1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the MARK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MARK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MARK1

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Andere Bezeichnung: MARK1

Hintergrund: MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK

UniProt: Q9P0L2

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion