LOX
Reaktivität: Human
WB, ELISA, FACS
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Titration of the LOX antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:500
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the LOX antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
LOX
(Lysyl Oxidase (LOX))
Andere Bezeichnung
LOX
Hintergrund
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.