L1CAM Antikörper (AA 1154-1182)

Produktnummer ABIN3031578

Dieses Anti-L1CAM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von L1CAM in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für L1CAM Antikörper (AA 1154-1182) (ABIN3031578)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser L1CAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-L1CAM Antikörper

Bindungsspezifität: AA 1154-1182

Kreuzreaktivität (Details): Expected species reactivity: Rat

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 1154-1182 from the human protein was used as the immunogen for this L1CAM antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the L1CAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. Cleavage by ADAM10 results in 180 and 40 kDa bands while cleavage by Plasmin results in 140 and 80 kDa bands.\. Western blot: 1:1000 (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the L1CAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Andere Bezeichnung: L1CAM

Hintergrund: L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

UniProt: P32004

Pathways: Synaptic Membrane