Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ISG15 Antikörper (AA 136-165)

This anti-ISG15 antibody (ABIN3031503) is a Rabbit Polyclonal antibody detecting ISG15 in WB, ELISA. Suitable for Human.
Produktnummer ABIN3031503

Kurzübersicht für ISG15 Antikörper (AA 136-165) (ABIN3031503)

Target

Alle ISG15 Antikörper anzeigen
ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

Reaktivität

  • 60
  • 7
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 56
  • 7
  • 1
Kaninchen

Klonalität

  • 49
  • 15
Polyklonal

Konjugat

  • 44
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ISG15 Antikörper ist unkonjugiert

Applikation

  • 48
  • 34
  • 28
  • 9
  • 8
  • 7
  • 5
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 136-165

    Aufreinigung

    Purified

    Immunogen

    A portion of amino acids 136-165 from the human protein was used as the immunogen for this ISG15 antibody.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    Titration of the ISG15 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    In 1X PBS pH 7.4 with 0.09 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Aliquot the ISG15 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

    Andere Bezeichnung

    ISG15

    Hintergrund

    ISG15 is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega , but not IFN-gamma . ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted also by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. The induction of terminal differentiation in human melanoma cells is associated with alterations in ISG15 expression. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog.

    UniProt

    P05161
Sie sind hier:
Chat with us!