FBXW7 Antikörper (N-Term)

Produktnummer ABIN3030899

Produktdetails anti-FBXW7 Antikörper

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antigen affinity purified

Immunogen: This FBXW7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the FBXW7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the FBXW7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Andere Bezeichnung: FBXW7 (FBXW7 Produkte)

Synonyme: cdc4 antikoerper, AGO antikoerper, CDC4 antikoerper, FBW6 antikoerper, FBW7 antikoerper, FBX30 antikoerper, FBXO30 antikoerper, FBXW6 antikoerper, SEL-10 antikoerper, SEL10 antikoerper, hAgo antikoerper, hCdc4 antikoerper, 1110001A17Rik antikoerper, Cdc4 antikoerper, Fbw7 antikoerper, Fbwd6 antikoerper, Fbx30 antikoerper, Fbxo30 antikoerper, Fbxw6 antikoerper, F-box and WD repeat domain containing 7 antikoerper, F-box and WD-40 domain protein 7 antikoerper, Fbxw7 antikoerper, FBXW7 antikoerper, fbxw7 antikoerper

Hintergrund: Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt]

UniProt: Q969H0

Pathways: Notch Signalweg, EGFR Signaling Pathway