Estrogen Receptor alpha Antikörper (AA 246-273)

Produktnummer ABIN3030876

Der Maus Monoklonal anti-Estrogen Receptor alpha Antikörper (Klon 415CT16-3-2-1) (ABIN3030876) detektiert spezifisch Estrogen Receptor alpha in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Estrogen Receptor alpha Antikörper (AA 246-273) (ABIN3030876)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 415CT16-3-2-1

Produktdetails anti-Estrogen Receptor alpha Antikörper

Bindungsspezifität: AA 246-273

Verwendungszweck: Estrogen Receptor alpha Antibody

Kreuzreaktivität (Details): Expected species reactivity: Bovine, Mouse, Pig, Rat

Aufreinigung: Purified

Immunogen: A portion of amino acids 246-273 from the human protein was used as the immunogen for this Estrogen Receptor alpha antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Titration of the Estrogen Receptor alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Estrogen Receptor alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: Estrogen Receptor alpha

Hintergrund: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly