Estrogen Receptor alpha Antikörper (Isoform 4)

Produktnummer ABIN3029713

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Estrogen Receptor alpha in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Estrogen Receptor alpha Antikörper (Isoform 4) (ABIN3029713)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Estrogen Receptor alpha Antikörper

Bindungsspezifität: AA 283-312, Isoform 4

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 283-312 from the human protein was used as the immunogen for this ER antibody (isoform 4).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Titration of the ER antibody (isoform 4) may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the ER antibody (isoform 4) and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: Estrogen Receptor (alpha)

Hintergrund: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly