DNMT3A Antikörper (AA 463-497)

Produktnummer ABIN3030748

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DNMT3A in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DNMT3A Antikörper (AA 463-497) (ABIN3030748)

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-DNMT3A Antikörper

Bindungsspezifität: AA 463-497

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Rat, Chicken

Aufreinigung: Antigen affinity purified

Immunogen: This Dnmt3a antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 463-497 amino acids from the central region of human Dnmt3a.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Dnmt3a antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu DNMT3A

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Andere Bezeichnung: Dnmt3a

Hintergrund: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

UniProt: Q9Y6K1