Dynamin 1-Like Antikörper (C-Term)

Produktnummer ABIN3030780

Dieses Anti-Dynamin 1-Like-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Dynamin 1-Like in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Dynamin 1-Like Antikörper (C-Term) (ABIN3030780)

Target: Dynamin 1-Like (DNM1L)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Dynamin 1-Like Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Dynamin 1-Like Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Antigen affinity purified

Immunogen: This DNM1L antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 513-547 amino acids from the C-terminal region of human DRP1/DNM1L.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the DNM1L antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:8000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the DNM1L antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Andere Bezeichnung: DNM1L

Hintergrund: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. [UniProt]

UniProt: O00429