DCLK2 Antikörper (AA 167-196)

Produktnummer ABIN3030772

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DCLK2 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DCLK2 Antikörper (AA 167-196) (ABIN3030772)

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-DCLK2 Antikörper

Bindungsspezifität: AA 167-196

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 167-196 from the human protein was used as the immunogen for this DCLK2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the DCLK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the DCLK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu DCLK2

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Andere Bezeichnung: DCLK2

Hintergrund: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

UniProt: Q8N568