CPT1C Antikörper (AA 752-782)

Produktnummer ABIN3030283

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CPT1C in WB, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CPT1C Antikörper (AA 752-782) (ABIN3030283)

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPT1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-CPT1C Antikörper

Bindungsspezifität: AA 752-782

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 752-782 from the human protein was used as the immunogen for this CPT1C antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the CPT1C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CPT1C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu CPT1C

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Andere Bezeichnung: CPT1C

Hintergrund: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.

UniProt: Q8TCG5

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process