BACE2C Antikörper (AA 310-339)

Produktnummer ABIN3029795

Produktdetails anti-BACE2C Antikörper

Target: BACE2C (BACE2 C) (beta-Site APP-Cleaving Enzyme 2 C (BACE2 C))

Bindungsspezifität: AA 310-339

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BACE2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Purified

Immunogen: A portion of amino acids 310-339 from the human protein was used as the immunogen for this BACE2C antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the BACE2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the BACE2C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu BACE2C

Target: BACE2C (BACE2 C) (beta-Site APP-Cleaving Enzyme 2 C (BACE2 C))

Andere Bezeichnung: BACE2C (BACE2 C Produkte)

Hintergrund: Amyloid-beta peptide aggregation is a signature of Alzheimer disease and a frequent complication of adult Down syndrome patients. Amyloid-beta is generated by proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretase at the N and C termini, respectively. Presenilin-1 is involved in the gamma-secretase activity. BACE is a transmembrane aspartyl protease with beta-secretase activity. BACE2, also termed ALP56 has 2 pepsin-like active centers, a signal sequence, a propeptide, and a long C-terminal extension including a transmembrane domain, with expression in a wide array of tissues. Northern blot analysis revealed low expression of 2.0- and 2.6-kb BACE2 transcripts in most fetal and adult tissues, with higher expression in adult colon, kidney, pancreas, placenta, prostate, stomach, and trachea. Low levels were also detected in brain, with somewhat higher expression in medulla and spinal cord. In situ hybridization analysis of rat brain found low-level BACE2 expression in contrast to BACE expression. The BACE2 expression pattern does not appear to be consistent with that of a beta-secretase. BACE2 has been mapped to 21q22.3, within the Down syndrome critical region.

UniProt: Q9Y5Z0