APP Antikörper (AA 735-763)
Kurzübersicht für APP Antikörper (AA 735-763) (ABIN3029685)
Target
Alle APP Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 735-763
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Verwendungszweck
- Amyloid beta Precusor Protein Antibody
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Kreuzreaktivität (Details)
- Expected species reactivity: Mouse, Pig, Primate, Rat
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Aufreinigung
- Antigen affinity
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Immunogen
- A portion of amino acids 735-763 from the human protein was used as the immunogen for this Amyloid beta precusor protein antibody.
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Isotyp
- Ig Fraction
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Applikationshinweise
- Titration of the Amyloid beta precusor protein antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the Amyloid beta precusor protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- APP (Amyloid beta (A4) Precursor Protein (APP))
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Andere Bezeichnung
- Amyloid beta Precusor Protein
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Hintergrund
- APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
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UniProt
- P05067
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Pathways
- Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Target
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