APP Antikörper (AA 735-763)

Produktnummer ABIN3029685

Dieses Anti-APP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von APP in WB und ELISA. Geeignet für Human.

Kurzübersicht für APP Antikörper (AA 735-763) (ABIN3029685)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-APP Antikörper

Bindungsspezifität: AA 735-763

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Pig, Primate, Rat

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 735-763 from the human protein was used as the immunogen for this Amyloid beta precusor protein antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Amyloid beta precusor protein antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Amyloid beta precusor protein antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Andere Bezeichnung: Amyloid beta Precusor Protein

Hintergrund: APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

UniProt: P05067

Pathways: Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour