DLG4 Antikörper (AA 581-724)

Produktnummer ABIN4952288

Dieses Anti-DLG4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DLG4 in WB und IHC (p). Geeignet für Ratte und Human.

Kurzübersicht für DLG4 Antikörper (AA 581-724) (ABIN4952288)

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Reaktivität: Ratte, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DLG4 Antikörper

Bindungsspezifität: AA 581-724

Aufreinigung: Antigen affinity

Immunogen: Amino acids 581-724 of human PSD95 were used as the immunogen for the PSD95 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PSD95 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the PSD95 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu DLG4

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Andere Bezeichnung: PSD-95

Hintergrund: DLG4 (Discs large homolog 4), also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase (MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.

UniProt: P78352

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity