GP2 Antikörper (AA 35-179)

Produktnummer ABIN4949728

Der Maus Monoklonal anti-GP2 Antikörper wird verwendet zum Nachweis von GP2 in Proben von Human. Er wurde validiert für FACS, IF und IHC (p).

Kurzübersicht für GP2 Antikörper (AA 35-179) (ABIN4949728)

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GP2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: GP2-1712

Produktdetails anti-GP2 Antikörper

Bindungsspezifität: AA 35-179

Keine Kreuzreaktivität: Maus

Aufreinigung: Protein G affinity chromatography

Immunogen: A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.

Isotyp: IgG2b lambda

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GP2 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/10e6 cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the GP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu GP2

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Andere Bezeichnung: Glycoprotein 2 / GP2 / ZAP75

Hintergrund: GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.