JUP Antikörper (full length)

Produktnummer ABIN4949716

Der Maus Monoklonal anti-JUP Antikörper wird verwendet zum Nachweis von JUP in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IF, FACS und IHC (p).

Kurzübersicht für JUP Antikörper (full length) (ABIN4949716)

Target: JUP (Junction Plakoglobin (JUP))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser JUP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: 15F11

Produktdetails anti-JUP Antikörper

Bindungsspezifität: full length

Verwendungszweck: Plakoglobin Antibody / Gamma Catenin (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Plakoglobin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu JUP

Target: JUP (Junction Plakoglobin (JUP))

Andere Bezeichnung: Plakoglobin

Hintergrund: Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt]

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location