Filaggrin Antikörper (AA 198-288)

Produktnummer ABIN4949675

Der Maus Monoklonal anti-Filaggrin Antikörper (Klon FLG-1561) (ABIN4949675) detektiert spezifisch Filaggrin in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Filaggrin Antikörper (AA 198-288) (ABIN4949675)

Target: Filaggrin (FLG)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Filaggrin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: FLG-1561

Produktdetails anti-Filaggrin Antikörper

Bindungsspezifität: AA 198-288

Verwendungszweck: Filaggrin Antibody (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Amino acids 198-288 of human FLG were used as the immunogen for this Filaggrin antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Filaggrin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Filaggrin

Target: Filaggrin (FLG)

Andere Bezeichnung: Filaggrin

Hintergrund: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance