Der Maus Monoklonal Anti-Desmoglein 1-Antikörper wurde für WB, IF, FACS und IP validiert. Er ist geeignet, Desmoglein 1 in Proben von Human zu detektieren.
Optimal dilution of the DSG1 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,WB: 0.5-1 μg/mL,Immunoprecipitation: suitable
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Konservierungsmittel
Azide free
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store the DSG1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Target
Desmoglein 1 (DSG1)
Andere Bezeichnung
Desmoglein 1 / DSG1
Hintergrund
Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.