Dityrosine Antikörper

Produktnummer ABIN492669

Dieses Anti-Dityrosine-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Dityrosine in WB, EIA und IHC (p). Geeignet für . Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Dityrosine Antikörper (ABIN492669)

Target: Dityrosine (DT)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Dityrosine Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1C3

Produktdetails anti-Dityrosine Antikörper

Aufreinigung: Protein A Chromatography

Immunogen: 3-(p-hydroxyphenyl) propionic acid dimer KLH-conjugated

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA (Ref.1,2)Western bLot (Ref.3,5)Immunohistochemistry on Paraffin Sections (Ref.4).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in 200 μL aqua bidest to 0.1 mg/mL

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °CAfter reconstitution, store as frozen aliquotsAvoid repeated freezing and thawingShelf life: One year from despatch.

Haltbarkeit: 12 months

Referenzen für anti-Dityrosine Antikörper (ABIN492669)

Li, Shi, Ding, Ran, Le: "Dietary oxidized tyrosine (O-Tyr) stimulates TGF-β1-induced extracellular matrix production via the JNK/p38 signaling pathway in rat kidneys." in: Amino acids, Vol. 49, Issue 2, pp. 241-260, (2018) (PubMed).

Details zu Dityrosine

Target: Dityrosine (DT)

Andere Bezeichnung: Dityrosine / DT

Substanzklasse: Dipeptide

Hintergrund: Tyrosine is one of the major targets of protein oxidation, and until today various tyrosine derivatives such as nitrotyrosine, dityrosine and halogenated tyrosine depending on the type of free radicals. DT is a tyrosine dimer derived from tyrosyl radicals which is formed by reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. DT have been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is one of the specific biomarkers for protein oxidation.