YES1 Antikörper

Produktnummer ABIN4915219

Dieser Maus Monoklonal Antikörper detektiert spezifisch YES1 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für YES1 Antikörper (ABIN4915219)

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser YES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 2C5

Produktdetails anti-YES1 Antikörper

Verwendungszweck: YES1 (2C5) Monoclonal Antibody

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein G.

Immunogen: This YES1 antibody is generated from a mouse immunized with a recombinant protein of human YES1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu YES1

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Andere Bezeichnung: YES1

Hintergrund:

Synonyms: Yes, c-yes, HsT441, P61-YES, Tyrosine-protein kinase Yes, Proto-oncogene c-Yes, YES1

Background: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Gen-ID: 7525

UniProt: P07947

Pathways: CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling