USP5 Antikörper

Produktnummer ABIN4915071

Der Maus Monoklonal anti-USP5 Antikörper (Klon 13C4) (ABIN4915071) detektiert spezifisch USP5 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für USP5 Antikörper (ABIN4915071)

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser USP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 13C4

Produktdetails anti-USP5 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu USP5

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Andere Bezeichnung: USP5

Hintergrund:

Synonyms: ISOT, Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, USP 5, USP-5

Background: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Gen-ID: 8078

UniProt: P45974