p63 Antikörper

Produktnummer ABIN4914776

Produktdetails anti-p63 Antikörper

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser p63 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This TP63 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from human TP63.

Klon: 3C3

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Andere Bezeichnung: TP63 (TP63 Produkte)

Synonyme: AIS antikoerper, B(p51A) antikoerper, B(p51B) antikoerper, EEC3 antikoerper, KET antikoerper, LMS antikoerper, NBP antikoerper, OFC8 antikoerper, RHS antikoerper, SHFM4 antikoerper, TP53CP antikoerper, TP53L antikoerper, TP73L antikoerper, p40 antikoerper, p51 antikoerper, p53CP antikoerper, p63 antikoerper, p73H antikoerper, p73L antikoerper, TP63 antikoerper, tp63 antikoerper, DNp63 antikoerper, id:ibd3516 antikoerper, tp73l antikoerper, wu:fc89f04 antikoerper, wu:fk85h07 antikoerper, wu:fk88b02 antikoerper, Ket antikoerper, P73l antikoerper, Tp73l antikoerper, Trp63 antikoerper, TRP63 antikoerper, AI462811 antikoerper, P51/P63 antikoerper, P63 antikoerper, Tp63 antikoerper, Trp53rp1 antikoerper, Xp63 antikoerper, ket antikoerper, np63 antikoerper, tp73l-A antikoerper, trp63 antikoerper, tumor protein p63 antikoerper, transformation related protein 63 antikoerper, tumor protein p63 L homeolog antikoerper, TP63 antikoerper, tp63 antikoerper, Tp63 antikoerper, Trp63 antikoerper, tp63.L antikoerper

Hintergrund:

Synonyms: AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B), Tumor protein 63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like

Background: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Gen-ID: 8626

UniProt: Q9H3D4