c-Rel Antikörper
Kurzübersicht für c-Rel Antikörper (ABIN4906804)
Target
Alle c-Rel Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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    - 
                                            Kreuzreaktivität
- Human
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                                            Aufreinigung
- Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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                                            Immunogen
- This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
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                                            Isotyp
- IgG2b
 
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    - 
                                            Applikationshinweise
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                        WB 1:300-5000
 IF()
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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    - 
                                            Format
- Liquid
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                                            Konzentration
- 0.5 μg/μL
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                                            Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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                                            Konservierungsmittel
- ProClin
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                                            Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            Lagerung
- -20 °C
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                                            Informationen zur Lagerung
- Store at -20°C for 12 months.
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                                            Haltbarkeit
- 12 months
 
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    - c-Rel (REL proto-oncogene (c-Rel))
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                                            Andere Bezeichnung
- C-rel
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                                            Hintergrund
- 
                        Synonyms: C-Rel, Proto-oncogene c-Rel, REL Background: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. 
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                                            Gen-ID
- 5966
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                                            UniProt
- Q04864
 Target
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