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c-Rel Antikörper

This anti-c-Rel antibody (ABIN4906804) is a Mouse Monoclonal antibody detecting c-Rel in WB, IF. Suitable for Human.
Produktnummer ABIN4906804

Kurzübersicht für c-Rel Antikörper (ABIN4906804)

Target

Alle c-Rel Antikörper anzeigen
c-Rel (REL proto-oncogene (c-Rel))

Reaktivität

  • 81
  • 23
  • 6
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 75
  • 9
  • 1
Maus

Klonalität

  • 68
  • 17
Monoklonal

Konjugat

  • 39
  • 7
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser c-Rel Antikörper ist unkonjugiert

Applikation

  • 57
  • 33
  • 13
  • 13
  • 11
  • 8
  • 5
  • 5
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (IF)

Klon

8C2
  • Kreuzreaktivität

    Human

    Aufreinigung

    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

    Immunogen

    This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.

    Isotyp

    IgG2b
  • Applikationshinweise

    WB 1:300-5000
    IF()

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.5 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    c-Rel (REL proto-oncogene (c-Rel))

    Andere Bezeichnung

    C-rel

    Hintergrund

    Synonyms: C-Rel, Proto-oncogene c-Rel, REL

    Background: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

    Gen-ID

    5966

    UniProt

    Q04864
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